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3,4-Dihydroxybenzoic acid
| Product Name | 3,4-Dihydroxybenzoic acid |
| Price: | $15 / 20mg |
| Catalog No.: | CN03945 |
| CAS No.: | 99-50-3 |
| Molecular Formula: | C7H6O4 |
| Molecular Weight: | 154.1 g/mol |
| Purity: | >=98% |
| Type of Compound: | Phenols |
| Physical Desc.: | Powder |
| Source: | The herbs of Onychium japonicum |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | OC(=O)c1ccc(c(c1)O)O |
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| Description | Protocatechuic acid is a phenolic compound which exhibits neuroprotective effect. |
| In Vitro | Protocatechuic acid inhibits the aggregation of Aβ and αS and destabilizes their preformed fibrils. Protocatechuic acid prevents the death of PC12 cells triggered by Aβ- and αS-induced toxicity[3]. |
| In Vivo | Protocatechuic acid is able to prevent stress induced immobility time in forced swim test without altering locomotor activity in mice. Further, Protocatechuic acid treatment attenuates the elevation of serum corticosterone, lipid peroxidation and restores enzymatic antioxidants in cerebral cortex and hippocampus in ARS mice[1]. Rat administered cadmium and treated with prostigmine and doses of Protocatechuic acid (10−20 mg/kg) has significantly reduced BChE activity. Cadmium and either prostigmine or Protocatechuic acid (10−20 mg/kg) treated rats shows significant reduction in MDA level[2]. |
| Cell Assay | Dilutions of Protocatechuic acid (2, 5, 10, 20, 50, and 100 μM) are prepared from stock solutions, with serum-free culture medium. Equal volumes of each solution are mixed with Aβ1-42 (10 μM), then incubated for 24 h on a thermoblock, with continuous agitation, and then exposed to PC12 cells for 24 h to test whether Protocatechuic acid can prevent cell death triggered by Aβ. Cell viability is determined by MTT reduction assay. Cells are treated with 200 μL per well of MTT solution (final concentration, 0.5 mg/mL in DMEM-Glutamax medium) for 3 h, at 37°C, with 5% CO2. The dark blue formazan crystals that formed are solubilized with 100 μL per well of DMSO, for 30 min. Absorbance is measured at 540 nm, with a microplate reader. Results are expressed as the percentage of MTT reduction in relation to the absorbance of control cells at 100%. |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 410.7±35.0 °C at 760 mmHg |
| Flash Point | 216.3±22.4 °C |
| Exact Mass | 154.026611 |
| PSA | 77.76000 |
| LogP | 1.16 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |