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Sophoraflavanone G
| Product Name | Sophoraflavanone G |
| Price: | $131 / 10mg |
| Catalog No.: | CN05149 |
| CAS No.: | 97938-30-2 |
| Molecular Formula: | C25H28O6 |
| Molecular Weight: | 424.5 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Powder |
| Source: | The roots of Sophora flavescens Ait. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CC(=CC[C@@H](C(=C)C)Cc1c(O)cc(c2c1O[C@@H](CC2=O)c1ccc(cc1O)O)O)C |
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| Description | Sophoraflavanone G (Kushenol F) is iaolated from Sophora flavescens and shows anti-tumor and anti-inflammatory properties. Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways[1][2]. |
| Target | IC50: 29.7 μM (MDA-MB-231 cell)[1] |
| In Vitro | Sophoraflavanone G (0 -100 μM; 24 hours) decreases the viability of the HL-60 cells in a dose-dependent manner[1]. Sophoraflavanone G (0 -100 μM; 24 hours) induces HL-60 cell apoptosis, activated caspase-3 and caspase-9, and downregulated Bcl-2 and Bcl-xL. It also upregulates Bax and released cytochrome c from the mitochondria into the cytoplasm, enabling apoptosis via the mitochondrially-mediated "intrinsic" pathway[1] Sophoraflavanone G (0 -40 μM; 24 hours) inhibits MDA-MB-231 cell viability in a concentration-dependent manner, with an IC50 value of 29.7 ± 5.2 μM[2]<.br> |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 659.3±55.0 °C at 760 mmHg |
| Flash Point | 224.8±25.0 °C |
| Exact Mass | 424.188599 |
| PSA | 107.22000 |
| LogP | 6.52 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Storage condition | 2-8℃ |