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Tanshindiol C
| Product Name | Tanshindiol C |
| Price: | Inquiry |
| Catalog No.: | CN08640 |
| CAS No.: | 97465-71-9 |
| Molecular Formula: | C18H16O5 |
| Molecular Weight: | 312.3 g/mol |
| Purity: | >=98% |
| Type of Compound: | Diterpenoids |
| Physical Desc.: | Powder |
| Source: | The roots of Salvia miltiorrhiza |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Tanshindiol C is a S-adenosylmethionine-competitive EZH2 (Histone Methyltransferase) inhibitor with an IC50 of 0.55 μM for inhibiting the methyltransferase activity. Tanshindiol C is also an activator of both Nrf2 and Sirtuin 1 (Sirt1) in macrophages. Tanshindiol C possesses anti-cancer activity, and can be used for atherosclerosis research[1][2]. |
| Target | EZH2:0.55 μM (IC50) SIRT1 |
| In Vitro | Tanshindiol C (1-10 μM; for 24 h) 激活 Nrf2 并上调巨噬细胞中的 Prdx1 表达和 mRNA 水平。Tanshindiol C 通过激活 Prdx1/ABCA1 信号通路保护巨噬细胞免受 oxLDL 诱导的泡沫细胞形成[1]。 Tanshindiol C 以相似的效力抑制 EZH2 野生型和 A667G 突变体 (Ki 值为 176 nM) 的活性[2]。 Tanshindiol C 抑制 Pfeiffer、U-2932 和 Daudi（淋巴瘤）、PC3（前列腺癌）、T98G 和 U87MG（胶质瘤）以及 A549（肺癌）等细胞系的生长，GI50 值分别为 1.5 μM、9.5 μM , 10.6 μM, 4 μM, 6 μM, 5.7 μM 和 4.2 μM[2]。 Tanshindiol C (1-5 μM; 72 hours) 诱导亚 G1 期 Pfeiffer 细胞聚集，表明细胞处于晚期凋亡和坏死[2]。 Tanshindiol C (1-3 μM; 72 hours) 增加细胞中重要的细胞凋亡相关蛋白标志物、cleaved caspase-3、caspase-7 和聚 ADP-核糖聚合酶 (PRAP) 的蛋白水平。Tanshindiol C 显着降低 细胞中的 H3K27me3[2]. RT-PCR[1] Cell Line: RAW264.7 cells Concentration: 1 μM, 3 μM, 10 μM Incubation Time: 24 h Result: Upregulated the Nrf2 and Prdx1 mRNA levels. Western Blot Analysis[1] Cell Line: Mouse peritoneal macrophages Concentration: 1 μM, 3 μM, 10 μM Incubation Time: 24 h Result: Activated Nrf2 and upregulated Prdx1 expression in macrophages. Cell Cycle Analysis[2] Cell Line: Pfeiffer cells Concentration: 1 μM, 2.5 μM and 5 μM Incubation Time: 72 hours Result: Induced accumulation of Pfeiffer cells in sub-G1 phase. Western Blot Analysis[2] Cell Line: Pfeiffer cells Concentration: 1 μM, 3 μM Incubation Time: 72 hours Result: The levels of H3K27me3 was significantly decreased in the cells. |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 561.5±50.0 °C at 760 mmHg |
| Flash Point | 293.4±30.1 °C |
| Exact Mass | 312.099762 |
| LogP | 2.25 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |