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Niga-ichigoside F1
| Product Name | Niga-ichigoside F1 |
| Price: | $293 / 5mg |
| Catalog No.: | CN07236 |
| CAS No.: | 95262-48-9 |
| Molecular Formula: | C36H58O11 |
| Molecular Weight: | 666.9 g/mol |
| Purity: | >=98% |
| Type of Compound: | Triterpenoids |
| Physical Desc.: | Powder |
| Source: | The tuberous roots of Potentilla anserina |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: | OC[C@H]1O[C@@H](OC(=O)[C@@]23CC[C@H]([C@@]([C@H]3C3=CC[C@H]4[C@@]([C@@]3(CC2)C)(C)CC[C@@H]2[C@]4(C)C[C@H]([C@@H]([C@@]2(C)CO)O)O)(C)O)C)[C@@H]([C@H]([C@@H]1O)O)O |
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| Description | Niga-ichigoside F1, an orally active ursane triterpenoid, has antihyperlipidemic and antioxidant activities. Niga-ichigoside F1 can prevent high-fat diet (HFD)-induced hepatic steatosis[1]. |
| In Vitro | Niga-ichigoside F1 (2.5, 5, 10, 20 μM; for 24 hours) inhibits lipid accumu-lation in free fatty acid (FFA)-treated HepG2 cells in a dose-dependent manner. Niga-ichigoside F1 has no effects on cell viability[1]. Both nuclear and cytoplasmic Nrf2 expressions are lowered in Con, Niga-ichigoside F1 (20 μM), FFA (1 mM), and Niga-ichigoside F1 plus FFA treated Nrf2-silenced cells[1]. |
| In Vivo | Niga-ichigoside F1 (40 mg/kg; oral gavage; for 12 weeks) alleviates hepatic steatosis, possibly by significantly interacting with high-fat diet (HFD) to regulate lipid metabolism genes (including Srebp1c, Acc1, Fasn, Scd1, Cpt1a and Fabp5) in four-week-old male C57BL/6J mice[1]. |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 775.0±60.0 °C at 760 mmHg |
| Flash Point | 234.7±26.4 °C |
| Exact Mass | 666.397888 |
| LogP | 3.84 |
| Vapour Pressure | 0.0±6.0 mmHg at 25°C |
| Storage condition | 2-8℃ |