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Gypenoside LI
| Product Name | Gypenoside LI |
| Price: | $511 / 5mg |
| Catalog No.: | CN07174 |
| CAS No.: | 94987-10-7 |
| Molecular Formula: | C42H72O14 |
| Molecular Weight: | 801.0 g/mol |
| Purity: | >=98% |
| Type of Compound: | Triterpenoids |
| Physical Desc.: | Powder |
| Source: | The herbs of Gynostemma pentaphyllum |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: |
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| Description | Gypenoside LI, a gypenoside monomer, possesses anti-tumor activity. Gypenoside LI induces cell apoptosis, cell cycle and migration[1][2]. |
| In Vitro | Gypenoside LI (0-80 μM) inhibits A549 cells in a dose-dependent manner. Gypenoside LI induces G2/M and arrest apoptosis in A549 cells[1]. Gypenoside LI increases intracellular ROS level. Gypenoside LI suppressed migration of A549 cells[1]. Gypenoside LI could obviously suppress the expression of CDK1 protein rather thanCDK2 and CDK4 proteins[1]. Gypenoside LI inhibits cell proliferation and upregulates expression of miR-128-3p in melanoma cells[2]. Gypenoside LI (75 and 29.71 μg/mL) can induce intrinsic apoptosis along with S phase arrest. Gypenoside LI inhibited the colony formation ability of melanoma through inhibition of the Wnt/β-catenin signaling pathway[2]. Gypenoside LI induces PARP cleavage, increased the expression of cleaved caspase-9 and BID death agonist, and downregulates the expression of FLIP (long form) and BCl-2 in the A375 and SK-MEL-28 melanoma cells[2]. Cell Viability Assay[1] Cell Line: A549 cells. Concentration: 0-80 μM. Incubation Time: 24 h. Result: Displayed the strongest activity with the IC50 values of 21.36 ± 0.78 μM. |
| Density | 1.33±0.1 g/cm3(Predicted) |
| Boiling Point | 912.3±65.0 °C(Predicted) |