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3,4-Dimethoxybenzoic acid
| Product Name | 3,4-Dimethoxybenzoic acid |
| Price: | $15 / 20mg |
| Catalog No.: | CN03953 |
| CAS No.: | 93-07-2 |
| Molecular Formula: | C9H10O4 |
| Molecular Weight: | 182.2 g/mol |
| Purity: | >=98% |
| Type of Compound: | Phenols |
| Physical Desc.: | Powder |
| Source: | The fruits of Phyllanthus emblica L. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1cc(ccc1OC)C(=O)O |
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| Description | Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant[1] and anti-inflammatory activities[3]. Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling[2]. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation[3]. |
| Target | COX-2[3] |
| In Vitro | Veratric acid (100, 200 μM) suppresses iNOS expression in LPS-stimulated RAW264.7 cells. Veratric acid (200 μM) inhibits LPS-induced activation of the PI3K/Akt pathway, HAT activation and HDAC3 expression in RAW264.7 cells[1]. Veratric Acid (10-100 μg/mL) has anti-inflammatory activity, protects HaCaT cells against UVB-mediated phototoxicity, increases S-phase cells, and prevents UVB-mediated apoptosis[3]. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation[3]. |
| In Vivo | Veratric acid (40 mg/kg, p.o., b.w.) significantly promotes ventricular function, reduces lipid peroxidation and increases antioxidants in l-NAME-induced hypertensive rats[2]. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 302.9±22.0 °C at 760 mmHg |
| Flash Point | 120.9±15.8 °C |
| Exact Mass | 182.057907 |
| PSA | 55.76000 |
| LogP | 1.99 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Storage condition | Refrigerator |