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Broussonin E
| Product Name | Broussonin E |
| Price: | Inquiry |
| Catalog No.: | CN03954 |
| CAS No.: | 90902-21-9 |
| Molecular Formula: | C17H20O4 |
| Molecular Weight: | 288.3 g/mol |
| Purity: | >=98% |
| Type of Compound: | Phenols |
| Physical Desc.: | Powder |
| Source: | The branches of Broussonetia papyrifera. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
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| Description | Broussonin E is a phenolic compound and shows anti-inflammatory activity. Broussonin E can suppress inflammation by modulating macrophages activation statevia inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway. Broussonin E can be used for the research of inflammation-related diseases such as atherosclerosis[1]. |
| Target | ERK p38 MAPK JAK2 STAT3 IL-1β IL-6 COX-2 IL-10 |
| In Vitro | Broussonin E (20 μM, 3 h) 抑制 LPS (Lipopolysaccharides，HY-D1056) 刺激的磷酸化 ERK 和 p38 MAPK[1]。 Broussonin E 可激活 janus 激酶 (JAK) 2、信号转导和转录激活因子 (STAT) 3[1]。 Broussonin E (0-20 μM, 3 h) 可抑制 RAW264.7 细胞中 LPS 诱导的促炎产生，包括 TNF-α、IL-1β、IL-6、COX-2 和 iNOS[1 ]. Broussonin E 增强 LPS 刺激的 RAW264.7 细胞中抗炎介质如 IL-10、CD206 和精氨酸酶-1 (Arg-1) 的表达[1]。 Western Blot Analysis[1] Cell Line: RAW264.7 cells Concentration: 2.5, 5, 10 and 20 Incubation Time: 3 h Result: Inhibited p-ERK and p-p38 MAPK, but not p-JNK MAPK expression in LPS-stimulated RAW264.7 cells. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 464.9±40.0 °C at 760 mmHg |
| Flash Point | 235.0±27.3 °C |
| Exact Mass | 288.136169 |
| PSA | 58.92000 |
| LogP | 3.35 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |