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Eckol
| Product Name | Eckol |
| Price: | Inquiry |
| Catalog No.: | CN03261 |
| CAS No.: | 88798-74-7 |
| Molecular Formula: | C18H12O9 |
| Molecular Weight: | 372.28 g/mol |
| Purity: | >=98% |
| Type of Compound: | Phenols |
| Physical Desc.: | Powder |
| Source: | The herbs of Ishige okamurae |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
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| Description | Eckol is a potent hMAO-A (Mixed) and hMAO-B (non-competitive) inhibitor with IC50s of 7.20 and 83.44 μM, respectively. Eckol shows stimulatory effects in maize and can be used as a plant biostimulant. Eckol also shows antiallergic and antiviral effects[1][2][3][4]. |
| Target | hMAO-A:7.20 μM (IC50) hMAO-B:83.44 μM (IC50) H1N1:89.5 μM (IC50) |
| In Vitro | Eckol (25-100 μg/mL; 2 h) 预处理以剂量依赖的方式显著降低 IgE/BSA 刺激的 BMCMC 中 β-hexosaminidase 的释放[3]。 Eckol (25-100 μg/mL; 1 h) 抑制 Th2 型细胞因子的产生，如 IL-4、IL-5、 IL-13 以及促炎细胞因子，如 IL-6[3]。 Eckol (25-100 μg/mL) 减弱 IgE/BSA 刺激的 BMCMC 细胞中细胞因子 mRNA 水平，如IL-1β、IL-4、IL-5、IL-6、IL-13、IFN-γ 和 TNF-α[3]。 Eckol (25-100 μg/mL; 1 h) 在 IgE/BSA 刺激的 BMCMC 中抑制 NF-κB 的激活[3]。 Eckol 抑制 influenza A/Bervig-Mission/1/18 (H1N1) 病毒，IC50 为 89.5 µM[4]。 Western Blot Analysis[3] Cell Line: Bone marrow-derived cultured mast cells (BMCMC) Concentration: 25, 50 and 100 μg/mL Incubation Time: 1 h Result: Inhibited the degradation of IκB-α within the cytosol and the translocation of the NF-κB/p65 subunit into the nucleus that were induced by IgE/BSA. |
| In Vivo | 叶面喷施 Eckol (1 μM) 显著提高了茎长和根长、茎干鲜重、叶面积和叶数[2]。 Eckol (50 or 100 μg/mouse; intradermal; once) 降低被动皮肤过敏反应 (PCA) 诱导小鼠的过敏性炎症反应[3]。 Animal Model: BALB/c mice (8 weeks old), IgE/BSA-induced passive cutaneous anaphylaxis (PCA) model[3] Dosage: 50 or 100 μg/mouse Administration: Intradermal injection, applied on mice ear 2 h prior to anaphylaxis induction Result: Reduced allergic inflammatory responses. |
| Density | 1.778g/cm3 |
| Boiling Point | 685.5ºC at 760 mmHg |
| Flash Point | 368.4ºC |
| Exact Mass | 372.04800 |
| PSA | 149.07000 |
| LogP | 3.61050 |