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Notopterol
| Product Name | Notopterol |
| Price: | $62 / 20mg |
| Catalog No.: | CN06265 |
| CAS No.: | 88206-46-6 |
| Molecular Formula: | C21H22O5 |
| Molecular Weight: | 354.40 g/mol |
| Purity: | >=98% |
| Type of Compound: | Coumarins |
| Physical Desc.: | Powder |
| Source: | The roots of Notopterygium incisum. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | C/C(=CCOc1c2ccoc2cc2c1ccc(=O)o2)/CC(C=C(C)C)O |
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| Use of Notopterol | Notopterol is a coumarin extracted from N. incisum. Notopterol induces apoptosis and has antipyretic, analgesic and anti-inflammatory effects. Notopterol is used for acute myeloid leukemia (AML)[1]. |
| In Vitro | notopterol (5, 10, 20, 40, 60 μM; for 48 hours) promotes cell apoptosis in a dose-dependent manner[1]. notopterol (10, 20, 40, 60 and 80 μM; 24-120 hours) inhibits the proliferation of HL-60 cells in a concentration-dependent manner[1]. Notopterol (5, 10, 20 and 40 μM; for 48 hours) induces G0/G1 phase arrest associated with cell-cycle proteins in HL-60 cells[1]. Notopterol (5, 10, 20 and 40 μM; for 48 hours) increases the expression of Bax and decreased the expression of Bcl-2 and Mcl-1 in HL-60 cells after 48-hr treatment. Moreover, Notopterol also promotes the cleavage of caspase 9, caspase 3 and PARP[1]. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 546.7±50.0 °C at 760 mmHg |
| Flash Point | 284.4±30.1 °C |
| Exact Mass | 354.146729 |
| PSA | 72.81000 |
| LogP | 4.25 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |