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AZ 628
| Product Name | AZ 628 |
| Price: | Inquiry |
| Catalog No.: | CN00178 |
| CAS No.: | 878739-06-1 |
| Molecular Formula: | C27H25N5O2 |
| Molecular Weight: | 451.52 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | N#CC(c1cccc(c1)C(=O)Nc1ccc(c(c1)Nc1ccc2c(c1)c(=O)n(cn2)C)C)(C)C |
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| Description | AZ628 is a pan-Raf kinase inhibitor with IC50s of 105, 34 and 29 nM for B-Raf, B-RafV600E, and c-Raf-1, respectively. |
| Target | c-Raf-1:29 nM (IC50) B-RafV600E:34 nM (IC50) B-Raf:105 nM (IC50) |
| In Vitro | AZ628 reduces activities of preactivated B-Raf, B-RafV600E, and c-Raf-1 in in vitro kinase assays, with IC50 values of 105, 34 and 29 nM, respectively. AZ628 also inhibits activation of number of tyrosine protein kinases including VEGFR2, DDR2, Lyn, Flt1, FMS and others. AZ628 inhibits anchorage-dependent and -independent growth, causes cell cycle arrest, and induces apoptosis in colon and melanoma cell lines harboring B-RafV600E mutation[1]. AZ-628 suppresses growth in cells expressing K-RASG13D. Inhibition of RAF with AZ-628 suppresses MEK and ERK phosphorylation. AZ-628 selectively affects viability in K-RAS mutant cells[2]. |
| Cell Assay | Cell viability quantified by Syto60 after 72 hours of AZ-628 (0.5, 1.0, and 1.5 μM), CI-1040 or BAY61-3606 treatment in HCT-116 (K-RASG13D/+) or HKe-3 (K-RAS-/+) cell lines. Relative cell viability is normalized to DMSO vehicle treated control for each cell line[2]. |
| Density | 1.2±0.1 g/cm3 |
| Exact Mass | 451.200836 |
| PSA | 99.81000 |
| LogP | 2.78 |
| Storage condition | ?20°C |