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Gramine
| Product Name | Gramine |
| Price: | $31 / 20mg |
| Catalog No.: | CN02101 |
| CAS No.: | 87-52-5 |
| Molecular Formula: | C11H14N2 |
| Molecular Weight: | 174.25 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Cryst. |
| Source: | The herbs of Arundo donax L. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CN(Cc1c[nH]c2c1cccc2)C |
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| Description | Gramine (Donaxine) is a natural alkaloid isolated from giant reed[2], acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 µM for AdipoR2 and AdipoR1, respectively[1]. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist[2]. Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties[1]. |
| Target | IC50: 3.2 µM (AdipoR2), 4.2 µM (AdipoR1)[1] |
| In Vitro | Gramine is an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 µM for AdipoR2 and AdipoR1, respectively[1]. Gramine is a potential β2-AR agonist[2]. Gramine (20 µM to 1.2 nM) dose-dependently inhibits the growth of AdipoR1/adipoR2-positive cancer cell lines (MDA-MB-231 and MCF-7 cells), with IC50s of 9.6±0.9 and 0.1±0.1 µM, respectively[1]. |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 293.9±15.0 °C at 760 mmHg |
| Flash Point | 131.5±20.4 °C |
| Exact Mass | 174.115692 |
| PSA | 19.03000 |
| LogP | 1.90 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Storage condition | Refrigerator (+4°C) |