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Homatropine
| Product Name | Homatropine |
| Price: | Inquiry |
| Catalog No.: | CN00622 |
| CAS No.: | 87-00-3 |
| Molecular Formula: | C16H21NO3 |
| Molecular Weight: | 275.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The herbs of Atropa belladonna L. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Homatropine is an orally active muscarinic acetylcholine receptor antagonist and can be used as an anticholinergic agent[1]. |
| In Vitro | Homatropine (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs, and produces a dose ratio of only 95.0 when combined with Hexamethonium Bromide (HY-B0569) in atrium from guinea-pigs[1]. Homatropine has affinities for muscarinic receptors in stomach (pA2 = 7.13) and for those in atria mediating force (pA2 = 7.21) and rate (pA2 = 7.07) responses[2]. |
| In Vivo | Homatropine methylbromide (9 mm x 5 mm conical suppository) causes prompt blockade of the effects of vagal stimulation on pulse rate and of intravenous acetylcholine on blood pressure in rats[3]. Animal Model: Male albino rats[3] Dosage: 9 mm x 5 mm conical suppository Administration: By suppository Result: Blocked cardiovascular responses to vagal stimulation and acetylcholine; 10-20 min after insertion of the suppository the effects of vagal stimulation over a range of 2-16 Hz, 5 V, on pulse rate was virtually abolished and remained unchanged at 45-60 min. |
| Density | 1.21 g/cm3 |
| Boiling Point | 403.3ºC |
| Flash Point | 197.7ºC |
| Exact Mass | 275.15200 |
| PSA | 49.77000 |
| LogP | 1.82630 |