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Andropanolide
| Product Name | Andropanolide |
| Price: | Inquiry |
| Catalog No.: | CN08722 |
| CAS No.: | 869807-57-8 |
| Molecular Formula: | C20H30O5 |
| Molecular Weight: | 350.45 g/mol |
| Purity: | >=98% |
| Type of Compound: | Diterpenoids |
| Physical Desc.: | Powder |
| Source: | The herbs of Andrographis paniculata (Burm. f.) Nees |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | OCC1(C)C(O)CCC2(C1CCC(=C)C2CC=C1C(O)COC1=O)C |
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| Description | Andrographolide (Andro) is a small antagonist for NF-κB activation by covalent modifying reduced cysteine 62 of p50. Andrographolide is a bicyclic diterpenoid lactone mainly produced from the plant Andrographis (Andrographis paniculate).Andrographolide suppresses the activation of NF-κB in stimulated endothelial cells, which reduces the expression of cell adhesion molecule E-selectin and prevents E-selectin-mediated leukocyte adhesion, but has no effect on IκBα degradation, p50 and p65 nuclear translocation[1]. |
| In Vitro | Andrographolide (15 μM; 12 hours) inhibited the luciferase activities induced by TNF-α in a time-dependent manner with an IC50 of 10 μM[1]. Cell Proliferation Assay[1] Cell Line: 293 cells Concentration: 15 μM Incubation Time: 12 hours Result: Inhibited NF-κB activation induced by TNF-α. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 557.3±50.0 °C at 760 mmHg |
| Flash Point | 195.5±23.6 °C |
| Exact Mass | 350.209320 |
| PSA | 86.99000 |
| LogP | 1.62 |
| Vapour Pressure | 0.0±3.4 mmHg at 25°C |