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Curculigoside
| Product Name | Curculigoside |
| Price: | $77 / 20mg |
| Catalog No.: | CN03965 |
| CAS No.: | 85643-19-2 |
| Molecular Formula: | C22H26O11 |
| Molecular Weight: | 466.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Phenols |
| Physical Desc.: | Powder |
| Source: | The rhizomes of Curculigo orchioides Gaertn. |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: | OC[C@H]1O[C@@H](Oc2ccc(cc2COC(=O)c2c(OC)cccc2OC)O)[C@@H]([C@H]([C@@H]1O)O)O |
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| Description | Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway[1]. |
| Target | JAK; STAT; NF-κB[1] |
| In Vitro | Curculigoside (1-64 μg/ml; 72 hours) exerts significant inhibitory effects on MH7A cell viability between 1 and 64 µg/ml in MH7A cells[1]. Curculigoside (4-16 μg/ml; 24 hours) decreases the protein expression of JAK1, JAK3 and STAT3 compared to the TNF-α group[1]. Cell Viability Assay[1] Cell Line: MH7A cells Concentration: 1 μg/ml; 2 μg/ml; 4 μg/ml; 8 μg/ml; 16 μg/ml; 32 μg/ml; 64 μg/ml Incubation Time: 72 hours Result: Had inhibitory effect on MH7A cells. Western Blot Analysis[1] Cell Line: MH7A cells Concentration: 4 μg/ml; 64 μg/ml Incubation Time: 24 hours Result: Downregulated JAK1, JAK3 and STAT3 protein expression. |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 734.9±60.0 °C at 760 mmHg |
| Flash Point | 253.8±26.4 °C |
| Exact Mass | 466.147522 |
| PSA | 164.37000 |
| LogP | -0.02 |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |