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Kurarinol
| Product Name | Kurarinol |
| Price: | Inquiry |
| Catalog No.: | CN05025 |
| CAS No.: | 855746-98-4 |
| Molecular Formula: | C26H32O7 |
| Molecular Weight: | 456.5 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Powder |
| Source: | The roots of Sophora flavescens |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive tyrosinase inhibitor, with IC50 of 0.1 μM for mushroom tyrosinase[1]. |
| Target | IC50: 0.1 μM (mushroom tyrosinase)[1] |
| In Vitro | Kurarinol manifests relatively low cytotoxic activity (EC50>30 μM)[1]. Kurarinol inhibits production of melanin in S. bikiniensis without affecting the growth of microorganism[1]. Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling (STAT3)[2]. |
| In Vivo | Kurarinol (20 mg/kg; p.o.; daily; for 3 days) reduced serum lipid levels in high-Cholesterol diet induced hyperlipidemic rats[3]. Animal Model: Male Sprague-Dawley rats (120-130g), hypercholesterolemic models[3] Dosage: 20 mg/kg Administration: Oral administration, daily, for 3 days Result: Decreased serum TC, TG, and LDL-C levels. |
| Exact Mass | 456.21500 |
| PSA | 116.45000 |
| LogP | 4.80440 |