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Arglabin
| Product Name | Arglabin |
| Price: | $439 / 10mg |
| Catalog No.: | CN09128 |
| CAS No.: | 84692-91-1 |
| Molecular Formula: | C15H18O3 |
| Molecular Weight: | 246.30 g/mol |
| Purity: | >=98% |
| Type of Compound: | Sesquiterpenoids |
| Physical Desc.: | Powder |
| Source: | The herbs of Artemisia glabella. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CC1=CC[C@]23[C@H]1[C@H]1OC(=O)C(=C)[C@@H]1CC[C@@]3(O2)C |
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| Description | Arglabin is a sesquiterpene gamma-lactone is isolated from Artemisia glabella; anticancer natural compound.IC50 value:Target: anticancerin vitro: Arglabin-stimulated macrophages displayed a strong cytotoxic activity and the lowest doses (1.25 micrograms/mL and 0.125 micrograms/mL) induced a significant stimulation of cell mitochondrial metabolism, which correlated with [3H]TdR uptake by J774.1 cells under the same experimental conditions. Arglabin triggered the production of the three cytokines from J774-1 cells. However, the pattern of cytokine secretion differed to some extent, according to the methodology used for cytokine measurement: either traditional bioassay or specific immunoassay (ELISA) [1]. Arglabin exhibits antiexudative and antiproliferative properties on the models of acute aseptic inflammation caused by formalin, carrageenan, and histamine, and on the model of proliferative inflammation accompanying cotton-pellet granuloma [2]. Arglabin is able to reduce the proportion of AML stem cells (CD34+CD38-) in primary AML cells [3]. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 404.6±45.0 °C at 760 mmHg |
| Flash Point | 171.3±23.3 °C |
| Exact Mass | 246.125595 |
| PSA | 38.83000 |
| LogP | 1.74 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |