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Xanthoxyletin
| Product Name | Xanthoxyletin |
| Price: | Inquiry |
| Catalog No.: | CN06129 |
| CAS No.: | 84-99-1 |
| Molecular Formula: | C15H14O4 |
| Molecular Weight: | 258.3 g/mol |
| Purity: | >=98% |
| Type of Compound: | Coumarins |
| Physical Desc.: | Powder |
| Source: | The barks of Zanthoxylum elephantiasis. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Xanthoxyletin is a coumarin that can be isolated from Genus Zanthoxylum and Clausena. Xanthoxyletin has antioxidant and anti-inflammatory activities. Xanthoxyletin shows cytotoxic effects to cancer cells, and induces apoptosis and necrosis. Xanthoxyletin can be used for the research of cancer and inflammation[1][2]. |
| In Vitro | Xanthoxyletin (1-500 µM；30 分钟) 抑制 DPPH 自由基的 IC50 值为 247.1 μM 和 63.8 μg/mL，对铁还原抗氧化能力 (FRAP) 的值为 45.2 μM[2]。 Xanthoxyletin (10-500µM；24 小时) 对 HepG2，HCT116 和 SK-LU-1 癌细胞具有细胞毒性，IC50 值分别为 78.2，79.8 和 94.4 μM[2]。 Xanthoxyletin (78 和 156 μM；12 和 24 小时) 诱导细胞凋亡，引起低坏死[2]。 Cell Cytotoxicity Assay[2] Cell Line: HepG2, HCT116, SK-LU-1 and Vero cell lines Concentration: 10-500 µM Incubation Time: 24 hours Result: Exhibited cytotoxicity to HepG2, HCT116 and SK-LU-1, but showed inactive effect to Vero cells. Apoptosis Analysis[2] Cell Line: HepG2 cell line[2] Concentration: 78 and 156 μM Incubation Time: 12 and 24 hours Result: Induced apoptosis percentage of 49.6% and 64.2% at the dose of 78 and 156 μM, respectively. Showed a better apoptosis inducing effect that cisplatin. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 438.6±45.0 °C at 760 mmHg |
| Flash Point | 197.2±28.8 °C |
| Exact Mass | 258.089203 |
| PSA | 48.67000 |
| LogP | 3.64 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |