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Stigmasterol
| Product Name | Stigmasterol |
| Price: | $18 / 20mg |
| Catalog No.: | CN02497 |
| CAS No.: | 83-48-7 |
| Molecular Formula: | C29H48O |
| Molecular Weight: | 412.7 g/mol |
| Purity: | >=98% |
| Type of Compound: | Steroids |
| Physical Desc.: | Powder |
| Source: | The herbs of Delphinium grandiflorum L. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CCC(C(C)C)C=CC(C1CCC2C1(C)CCC1C2CC=C2C1(C)CCC(C2)O)C |
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| Description | Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases. |
| Target | MMP[1] |
| In Vitro | Preincubation of Stigmasterol to IL-1beta-treated cells shows significant reduction of MMP-3 mRNA in human and mouse, MMP-3 protein in mouse, MMP-13 mRNA in mouse and human, ADAMTS-4 mRNA in human, PGE2 protein in human and mouse. Stigmasterol is also capable of counteracting the IL-1beta-induced NF-κB pathway[1]. |
| Cell Assay | A model of newborn mouse chondrocytes and human osteoarthritis (OA) chondrocytes are used in primary culture stimulated with or without IL-1β (10 ng/mL), for 18 h. Cells are pre-incubated with Stigmasterol (20 mg/mL) for 48 h[1]. |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 501.1±19.0 °C at 760 mmHg |
| Flash Point | 219.4±13.7 °C |
| Exact Mass | 412.370514 |
| PSA | 20.23000 |
| LogP | 10.21 |
| Vapour Pressure | 0.0±2.9 mmHg at 25°C |
| Storage condition | 2~8°C |