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28-Homobrassinolide
| Product Name | 28-Homobrassinolide |
| Price: | Inquiry |
| Catalog No.: | CN02281 |
| CAS No.: | 82373-95-3 |
| Molecular Formula: | C29H50O6 |
| Molecular Weight: | 494.7 g/mol |
| Purity: | >98% |
| Type of Compound: | Steroids |
| Physical Desc.: | Powder |
| Source: | The herbs of Brassica napus |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | 28-Homobrassinolide is a phytosteroid. 28-Homobrassinolide can be used for the research of cholesterol and glucose homeostasis[1]. |
| In Vitro | 28-Homobrassinolide (5-20 μM) 表明 HepG2 细胞中的葡萄糖利用以及 ABCA1 和 SREBP2 蛋白表达增加了 2 倍[1]。 28-Homobrassinolide 降低组织葡萄糖和胆固醇水平，增加胆固醇水平和组织己糖激酶活性[1]。 Cell Cytotoxicity Assay[1] Cell Line: HepG2 cells Concentration: 1 µM, 5 µM, 10 µM, 20 µM, 30 µM, 40 µM, and 80 µM Incubation Time: 24 h Result: The IC50 value of 40.57µM obtained by the MTT assay. Western Blot Analysis[1] Cell Line: HepG2 cells Concentration: 5, 10, and 20 μM Incubation Time: 12 h Result: Exhibited an increase in both ABCA1 and SREBP2 markers. |
| In Vivo | 28-HB（1-20 μg/天；持续 6 周）显示高脂肪饮食喂养的 C57BL/6 小鼠的主动脉脂肪沉积和血清标志物水平显着降低[1]。 Animal Model: High-fat diet-fed C57BL/6 mice[1] Dosage: 1-20 μg/day Administration: For 6 weeks Result: Observed a significant decrease in lipid deposition. |
| Exact Mass | 494.36100 |
| PSA | 107.22000 |
| LogP | 3.78010 |