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Coelonin
| Product Name | Coelonin |
| Price: | Inquiry |
| Catalog No.: | CN03830 |
| CAS No.: | 82344-82-9 |
| Molecular Formula: | C15H14O3 |
| Molecular Weight: | 242.3 g/mol |
| Purity: | >=98% |
| Type of Compound: | Phenols |
| Physical Desc.: | Powder |
| Source: | The herbs of Bletilla striata |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
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| Description | Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits NF-κB activation and p27Kip1 degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein[1][2]. |
| Target | Akt NF-κB IL-1β IL-6 |
| In Vitro | Coelonin (2.5 μg/mL) 显著降低 NF-κB p65 和 p105/50 磷酸化水平[1]。 Coelonin (0-5 μg/mL, 1.5 h) 剂量依赖性地降低 LPS 诱导的 PTEN、AKT 和 IκBa 磷酸化的增加[1]。 Coelonin (10 和 20 μg/ml) 通过减少炎症因子(包括白细胞介素 6 (IL-6) 和肿瘤坏死因子-α (TNF-α)) 的产生来减轻颗粒物 2.5 (PM2.5) 诱导的炎症< sup>[2]. Coelonin 对 IL-1β、IL-6 和 TNF-α 表达的抑制与 PTEN 无关，而对 p27Kip1 降解的抑制导致细胞周期停滞在 G1 期，这依赖于 PTEN[1] . Western Blot Analysis[1] Cell Line: RAW264.7 cells Concentration: 0, 1, 2.5, and 5 μg/mL Incubation Time: 1.5 h Result: Dose dependently reduced the increase of p65 accumulation in the nucleus induced by LPS. Dose dependently reversed LPS-induced iNOS and COX2 expression. LPS (200 ng/mL) significantly increased the phosphorylation of PTEN, AKT and inhibitor of NF-κB (IκBa), which was dose-dependently reduced by coelonin pre-treatment. |
| Exact Mass | 242.09400 |
| PSA | 49.69000 |
| LogP | 2.87200 |
| Storage condition | -20℃ |