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Yakuchinone A
| Product Name | Yakuchinone A |
| Price: | $219 / 5mg |
| Catalog No.: | CN03234 |
| CAS No.: | 78954-23-1 |
| Molecular Formula: | C20H24O3 |
| Molecular Weight: | 312.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Phenols |
| Physical Desc.: | Powder |
| Source: | The rhizomes of Curcuma longa L. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Yakuchinone A is a natural product isolated from the fruit of Alpinia oxyphylla, which can induce apoptosis and has anticancer and anti-inflammatory activities[1]. |
| In Vitro | Yakuchinone A 作用于 A375P、B16F1、B16F10、A549、MCF-7 和 HT-29 细胞系的 IC50 值分别是 14.75、31.73、21.71、26.07 、11.50 和 11.96[1]。 Yakuchinone A (0-64 μM, 16 h) 可以剂量依赖性方式减少 IL-17 的产生，在 EL4（小鼠淋巴瘤细胞系）细胞中的 IC50 值为 11.5 μM[2] 。 |
| In Vivo | Yakuchinone A (50 mg/kg, i.p., daily, 14 days) 在自身免疫性脑脊髓炎 (EAE) 小鼠模型中可以减轻小鼠的 EAE 症状[1]。 Animal Model: Female C57BL/6 mice[1] Dosage: 50 mg/kg Administration: i.p., daily, 14 days Result: Showed a significant EAE score reduction from Day 9 to Day 15 after EAE onset. |
| Density | 1.095g/cm3 |
| Boiling Point | 495.8ºC at 760 mmHg |
| Flash Point | 174.3ºC |
| Exact Mass | 312.17300 |
| PSA | 46.53000 |
| LogP | 4.31550 |
| Storage condition | 2-8°C |