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Hydroxysafflor yellow A
| Product Name | Hydroxysafflor yellow A |
| Price: | $54 / 20mg |
| Catalog No.: | CN05694 |
| CAS No.: | 78281-02-4 |
| Molecular Formula: | C27H32O16 |
| Molecular Weight: | 612.53 g/mol |
| Purity: | >=98% |
| Type of Compound: | Chalcones |
| Physical Desc.: | Yellow powder |
| Source: | The stigma of Crocus sativus L. |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: | OC[C@H]1O[C@H]([C@@H]([C@H]([C@@H]1O)O)O)C1=C(O)C(C(=C(C1=O)C(=O)/C=C/c1ccc(cc1)O)O)(O)[C@@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O |
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| Description | Hydroxysafflor yellow A is a flavonoid derived and isolated from traditional Chinese medicine Carthamus tinctorius L., possesses anti-tumor activity. IC50 value:Target: in vitro: HYSA could inhibit LPS-induced VSMCs proliferation and migration, accompanied by the downregulated levels of several key pro-inflammatory cytokines, including TNF-α, IL-6, and IL-8. We further showed that HYSA inhibited LPS-induced upregulation of TLR-4 expression as well as the activation of Rac1/Akt pathway [1]. HSYA protected EC viability against LPS-induced injury (P<0.05). LPS-induced NF-κB p65 subunit DNA binding (P<0.01) and nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor -α (I-κB-α) phosphorylation was inhibited by HSYA. HSYA attenuated LPS triggered ICAM-1 and E-selectin mRNA levels elevation and phosphorylation of p38 MAPK or c-Jun N-terminal kinase MAPK [2]. HSYA inhibited the proliferation of 3T3-L1 preadipocytes and cell viability greatly decreased in a dose and time dependent manner. HSYA (1 mg/l) notably reduced the amount of intracellular lipid and triglyceride content in adipocytes by 21.3 % (2.13 ± 0.36 vs 2.71 ± 0.40, P < 0.01) and 22.6 % (1.33 ± 0.07 vs 1.72 ± 0.07, P < 0.01) on days 8 following the differentiation, respectively [3]. in vivo: HSYA treatment ameliorated serum biochemical indicators by reducing the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), hyaluronan (HA), laminin (LN), and type III precollagen (III-C) in rats [4]. |
| Density | 1.9±0.1 g/cm3 |
| Boiling Point | 1015.8±65.0 °C at 760 mmHg |
| Flash Point | 334.0±27.8 °C |
| Exact Mass | 612.169006 |
| PSA | 295.36000 |
| LogP | 2.98 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |