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Corylifol A
| Product Name | Corylifol A |
| Price: | $190 / 20mg |
| Catalog No.: | CN05082 |
| CAS No.: | 775351-88-7 |
| Molecular Formula: | C25H26O4 |
| Molecular Weight: | 390.5 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Yellow powder |
| Source: | The seeds of Psoralea corylifolia L. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | C/C(=CCc1cc(ccc1O)c1coc2c(c1=O)ccc(c2)O)/CCC=C(C)C |
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| Description | Corylifol A inhibits IL-6-induced STAT3 activation and phosphorylation, with an IC50 of 0.81 μM. |
| Target | STAT3:0.81 μM (IC50) |
| In Vitro | Corylifol A shows an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 value of 0.81±0.15 μM, also inhibits STAT3 phosphorylation induced by IL-6 in Hep3B cells[1]. Corylifol A inhibits SARA PLpro in a dose-dependent manner with IC50s ranging between 4.2 and 38.4 μM[2]. Corylifol A is found to be a naturally occurring potent inhibitor of hCE2, with low Ki values ranging from 0.62 μM to 3.89 μM[3]. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 609.3±55.0 °C at 760 mmHg |
| Flash Point | 208.8±25.0 °C |
| Exact Mass | 390.183105 |
| PSA | 70.67000 |
| LogP | 6.91 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Storage condition | -20°C |