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Camptothecin
| Product Name | Camptothecin |
| Price: | Inquiry |
| Catalog No.: | CN01561 |
| CAS No.: | 7689-03-4 |
| Molecular Formula: | C20H16N2O4 |
| Molecular Weight: | 348.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The barks of Camptotheca acuminata Decne. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CC[C@@]1(O)C(=O)OCc2c1cc1c3nc4ccccc4cc3Cn1c2=O |
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| Description | Campathecin is a potent DNA enzyme topoisomerase I inhibitor, with an IC50 of 679 nM. |
| Target | Topoisomerase I:679 nM (IC50) |
| In Vitro | [3H]BrCPT labeling of topoisomerase I is enhanced greatly by the presence of DNA; very little labeling of isolated topoisomerase I or isolated DNA occurrs. Even in the presence of DNA, [3H]BrCPT labeling of topoisomerase I is inhibited by camptothecin, suggesting that both CPT and BrCPT bind to the same site on the DNA-topoisomerase I binary complex[1]. With increasing concentrations of camptothecin, closed circular pRR322 DNA (form I) is converted to nicked circular DNA (form 11). This apparent nicking activitv of camptothecin required DNA topoisomerase I[2]. |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 757.0±60.0 °C at 760 mmHg |
| Flash Point | 411.6±32.9 °C |
| Exact Mass | 348.110992 |
| PSA | 81.42000 |
| LogP | 1.60 |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |