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Derrone
| Product Name | Derrone |
| Price: | Inquiry |
| Catalog No.: | CN05201 |
| CAS No.: | 76166-59-1 |
| Molecular Formula: | C20H16O5 |
| Molecular Weight: | 336.34 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Yellow powder |
| Source: | The herbs of Cudrania tricuspidata |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Derrone, a prenylated isoflavones, is an Aurora kinase inhibitor, with IC50 values of 6 and 22.3 μM against Aurora B and Aurora A, respectively. Derrone shows anti-tumor activity[1][2]. |
| Target | IC50: 6 μM (Aurora kinase B), 22.3 μM (Aurora kinase A)[1] |
| In Vitro | Derrone (30-60 μM, 15 days) significantly inhibits the formation and growth of MCF7 tumor spheroids, with the tumor spheroid growth inhibition (% TGI) of 17.5% and 65.4% for 30 and 60 μM Derrone, respectively[1]. Derrone shows the autophagic features, such as the conversion of LC3-I to LC3-II, the formation of autophagosome and the downregulation of SQSTM1/p62 (p62)[2]. Derrone induces autophagic cell death through intracellular ROS and sustained ERK phosphorylation in A549 cells[2]. |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 584.1±50.0 °C at 760 mmHg |
| Flash Point | 214.6±23.6 °C |
| Exact Mass | 336.099762 |
| PSA | 79.90000 |
| LogP | 5.53 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |