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Tephrosin
| Product Name | Tephrosin |
| Price: | $249 / 10mg |
| Catalog No.: | CN05068 |
| CAS No.: | 76-80-2 |
| Molecular Formula: | C23H22O7 |
| Molecular Weight: | 410.43 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Cryst. |
| Source: | The herbs of Derris robusta |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Tephrosin is a natural rotenoid which has potent antitumor activities. Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors[1]. |
| In Vitro | Treatment of HT-29 cells with tephrosin (0-10μM) inhibits both the ligand-induced and constitutive phosphorylation of EGFR, ErbB2 and ErbB3, and concomitantly suppresses the activation of the downstream signaling molecules such as Akt and Erk1/2 mitogen-activated protein kinase (MAPK) [1]. |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 623.4±55.0 °C at 760 mmHg |
| Flash Point | 219.3±25.0 °C |
| Exact Mass | 410.136566 |
| PSA | 83.45000 |
| LogP | 4.48 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Storage condition | ?20°C |