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Quassin
| Product Name | Quassin |
| Price: | $439 / 5mg |
| Catalog No.: | CN08772 |
| CAS No.: | 76-78-8 |
| Molecular Formula: | C22H28O6 |
| Molecular Weight: | 388.5 g/mol |
| Purity: | >=98% |
| Type of Compound: | Diterpenoids |
| Physical Desc.: | Powder |
| Source: | The barks of Quassia amara L. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits P. falciparum with an IC50 of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity[1][2]. |
| Target | IC50: 0.15 μM (P. falciparum)[2] |
| In Vitro | Quassin (Compound 1; 5-25 ng/mL) inhibits both the basal and luteinizing hormone-stimulated testosterone secretion of rat Leydig cells in a dose-dependent fashion[3]. |
| In Vivo | Quassin (0.1-2.0 mg/kg; oral administration; daily; for 60 days; females albino rats) treatment shows a significant decrease in the weight of the ovary and uterus. And also shows a significant decrease in serum estrogen levels in quassin treated rats. The Quassin treated rats has a significantly decreased mean litter number and weight. Quassin does not adversely affect the weight of the kidney, heart, liver and the body of the rats[1]. Animal Model: 35 females albino rats (150-170 g)[1] Dosage: 0.1 mg/kg, 1.0 mg/kg and 2.0 mg/kg Administration: Oral administration; daily; for 60 days Result: There was a significant decrease in the weight of the ovary and uterus in all the groups relative to the control. There was also a significant decrease in serum estrogen levels in quassin treated rats. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 586.3±50.0 °C at 760 mmHg |
| Flash Point | 255.4±30.2 °C |
| Exact Mass | 388.188599 |
| PSA | 78.90000 |
| LogP | 2.22 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Storage condition | 2-8℃ |