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Lovastatin
| Product Name | Lovastatin |
| Price: | Inquiry |
| Catalog No.: | CN08875 |
| CAS No.: | 75330-75-5 |
| Molecular Formula: | C24H36O5 |
| Molecular Weight: | 404.54 g/mol |
| Purity: | >=98% |
| Type of Compound: | Diterpenoids |
| Physical Desc.: | Powder |
| Source: | The secondary metabolite produced by filamentous fungi. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CC[C@@H](C(=O)O[C@H]1C[C@@H](C)C=C2[C@H]1[C@@H](CC[C@@H]1C[C@@H](O)CC(=O)O1)[C@H](C=C2)C)C |
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| Description | Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol. |
| Target | HMG-CoA reductase[1] |
| In Vitro | Lovastatin is an inactive lactone prodrug that must be chemically or enzymatically converted to its dihydroxy open-acid form in order to elicit inhibitory activity. Lovastatin in its hydroxy acid form is an exceptionally potent competitive inhibitor of liver HMG CoA reductase[1]. Lovastatin, other than its anticholesterol property, has diverse applications in the field of osteoporosis, neuro-degeneration, rheumatoid arthritis, antifungals and also is reported to reduce proliferation of lung cancer cells, breast cancer (MCF-7), liver cancer (HepG2). Lovastatin treatments show significant dose dependent cytotoxic effect on HeLa cells with IC50 value of 160 μg/mL. Lovastatin is effective to accelerate hydroxyl radical scavenging activity (54.06%) at an IC50 of 3601 μg/mL[2]. |
| In Vivo | Lovastatin is an inactive lactone that is hydrolyzed in the liver to an active f3-hydroxyacid form. This principal metabolite is the inhibitor of the enzyme HMG-CoA reductase. The Ki is 1 nM. Lovastatin and its β-hydroxyacid metabolite are highly bound to human plasma proteins. Lovastatin crosses the blood-brain and placental barriers[3]. Lovastatin produces a profound reduction of apolipoprotein-B-containing lipoproteins, especially LDL cholesterol and, to a lesser extent, plasma triglycerides, and a small increase in HDL cholesterol[4]. |
| Cell Assay | Hela cells are treated with lovastatin (0, 5, 10, 20, 40, 80, 160, 320 μg/mL) for 24 h. Cells treated with culture medium serves as a negative control. cell viability is measured using the MTT based colorimetric assay [2]. |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 559.2±50.0 °C at 760 mmHg |
| Flash Point | 185.3±23.6 °C |
| Exact Mass | 404.256287 |
| PSA | 72.83000 |
| LogP | 4.07 |
| Vapour Pressure | 0.0±3.4 mmHg at 25°C |
| Storage condition | 2-8°C |