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Beta-Hydroxyisovalerylshikonin
| Product Name | Beta-Hydroxyisovalerylshikonin |
| Price: | $380 / 10mg |
| Catalog No.: | CN05870 |
| CAS No.: | 7415-78-3 |
| Molecular Formula: | C21H24O7 |
| Molecular Weight: | 388.42 g/mol |
| Purity: | >=98% |
| Type of Compound: | Quinones |
| Physical Desc.: | Solid |
| Source: | The roots of Lithosperraum erythrorhizon Sieb. et Zucc. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | O=C(CC(O)(C)C)O[C@@H](C1=CC(=O)c2c(C1=O)c(O)ccc2O)CC=C(C)C |
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| Description | Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermium radix, acts as a potent inhibitor of protein tyrosine kinases (PTK), with IC50s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells[1]. |
| Target | IC50: 0.7 μM (EGFR), 1 μM (v-Src)[1] |
| Density | 1.312g/cm3 |
| Boiling Point | 616.9ºC at 760 mmHg |
| Flash Point | 215.8ºC |
| Exact Mass | 388.15200 |
| PSA | 121.13000 |
| LogP | 2.83230 |