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5-Geranoxy-7-methoxycoumarin
| Product Name | 5-Geranoxy-7-methoxycoumarin |
| Price: | Inquiry |
| Catalog No.: | CN06030 |
| CAS No.: | 7380-39-4 |
| Molecular Formula: | C20H24O4 |
| Molecular Weight: | 328.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Coumarins |
| Physical Desc.: | Powder |
| Source: | The twigs of Toddalia asiatica |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1cc(OC/C=C(/CCC=C(C)C)C)c2c(c1)oc(=O)cc2 |
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| Description | 5-Geranoxy-7-methoxycoumarin is a coumarin with anti-cancer, antifungal, and antibacterial activities. 5-Geranoxy-7-methoxycoumarin induces cell apoptosis[1][2]. |
| In Vitro | 5-Geranoxy-7-methoxycoumarin (12.5-200 µM; 24-72 hours) induces a significant inhibition of cell growth in a time-dependent manner in SW480 cells[1]. 5-Geranoxy-7-methoxycoumarin (50 µM;48 hours) promotes DNA fragmentation and causes apoptosis through inhibition of the p38 MAPK signaling pathway in SW480 cells[1]. 5-Geranoxy-7-methoxycoumarin (50 µM; 24-48 hours) increases the percentage of cells in the sub G1/G0 phase from 5.3% (in control cells) to 18% after 48 h incubation[1]. Cell Proliferation Assay[1] Cell Line: SW480 Concentration: 0-20 μM Incubation Time: 24, 48 and 72 hours Result: Inhibited cell growth by 67% at 72 hours. Apoptosis Analysis[1] Cell Line: SW480 cells Concentration: 50 μM Incubation Time: 48 hours Result: Induced cell apoptosis. Cell Cycle Analysis[1] Cell Line: SW480 cells Concentration: 50 μM Incubation Time: 48 hours Result: Inhibited cell cycle progression in vitro. |
| Density | 1.092g/cm3 |
| Boiling Point | 487.1ºC at 760 mmHg |
| Flash Point | 213.2ºC |
| Exact Mass | 328.16700 |
| PSA | 48.67000 |
| LogP | 4.87310 |
| Storage condition | -20°C |