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Atractylenolide II
| Product Name | Atractylenolide II |
| Price: | $62 / 20mg |
| Catalog No.: | CN09486 |
| CAS No.: | 73069-14-4 |
| Molecular Formula: | C15H20O2 |
| Molecular Weight: | 232.32 g/mol |
| Purity: | >=98% |
| Type of Compound: | Sesquiterpenoids |
| Physical Desc.: | Powder |
| Source: | The rhizomes of Atractylodes macrocephala Koidz. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | C=C1CCC[C@]2([C@H]1CC1=C(C)C(=O)O[C@H]1C2)C |
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| Description | Atractylenolide II is a sesquiterpene compound isolated from the dried rhizome of Atractylodes macrocephala (Baizhu in Chinese); anti-proliferative activity.IC50 value: 82.3 μM(B16 melanoma cell, 48 h) [1]Target: anticancer natural compoundin vitro: AT-II treatment for 48 h dose-dependently inhibited cell proliferation with an IC(50) of 82.3 μM, and induced G1 phase cell cycle arrest. Moreover, treatment with 75 μM AT-II induced apoptosis. These observations were associated with the decrease of the expression of Cdk2, phosphorylated-Akt, phosphorylated-ERK and Bcl-2, the increase of the expression of phosphorylated-p38, phosphorylated-p53, p21, p27, and activation of caspases-8, -9 and -3. In addition, a chemical inhibitor of p53, PFTα, significantly decreased AT-II-mediated growth inhibition and apoptosis [1]. In B16 and A375 cells, AT-II (20, 40 μm) treatment for 48 h dose-dependently reduced protein expression levels of phospho-STAT3, phospho-Src, as well as STAT3-regulated Mcl-1 and Bcl-xL. Overexpression of a constitutively active variant of STAT3, STAT3C in A375 cells diminished the antiproliferative and apoptotic effects of AT-II [2].in vivo: Daily administration of AT-II (12.5, 25 mg/kg, i.g.) for 14 days significantly inhibited tumor growth in a B16 xenograft mouse model and inhibited the activation/phosphorylation of STAT3 and Src in the xenografts [2]. |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 378.0±41.0 °C at 760 mmHg |
| Flash Point | 158.7±25.0 °C |
| Exact Mass | 232.146332 |
| PSA | 26.30000 |
| LogP | 3.61 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Storage condition | -20°C |