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Atractylenolide III
| Product Name | Atractylenolide III |
| Price: | $62 / 20mg |
| Catalog No.: | CN09485 |
| CAS No.: | 73030-71-4 |
| Molecular Formula: | C15H20O3 |
| Molecular Weight: | 248.32 g/mol |
| Purity: | >=98% |
| Type of Compound: | Sesquiterpenoids |
| Physical Desc.: | Powder |
| Source: | The rhizomes of Atractylodes macrocephala Koidz. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | C=C1CCC[C@]2([C@H]1CC1=C(C)C(=O)O[C@]1(C2)O)C |
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| Description | Atractylenolide III is a major component of Atractylodes rhizome can induce apoptosis of the lung carcinoma cells.IC50 value:Target: Anticancer natural compoundin vitro: ATL-III inhibited cell growth, increased lactate dehydrogenase release and modulated cell cycle on human lung carcinoma A549 cells. ALT-III induced the activation of caspase-3 and caspase-9 and cleavage of poly-(ADP)-ribose polymerase. ATL-III induced the release of cytochrome c, upregulation of bax expression, and translocation of apoptosis-inducing factor [1]. Atractylenolide II did not show cytoprotective effects, but oral administration of atractylenolide III dose-dependently prevented ethanol-induced PRGM cell death and cell membrane damage. The EC50 values were 0.27 and 0.34 mm, respectively [2]. Against adult D. pteronyssinus, atractylenolide III (LD50, 73.8 mg/m2) and atractylon (72.1 mg/m2) were eight times more active than Deet and 2.5-fold more toxic than dibutyl phthalate [3].in vivo: In the in-vivo assay, atractylenolide III 10 mg/kg significantly reduced 70% ethanol-induced Wistar rat gastric ulcer. Atractylenolide III could inhibit matrix metalloproteinase (MMP)-2 and MMP-9 expression through upregulation of tissue inhibitors of metalloproteinase from the gastric ulcerated tissues [2]. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 424.6±45.0 °C at 760 mmHg |
| Flash Point | 181.1±21.5 °C |
| Exact Mass | 248.141251 |
| PSA | 46.53000 |
| LogP | 2.36 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Storage condition | 2-8°C |