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Cordycepin
| Product Name | Cordycepin |
| Price: | $23 / 20mg |
| Catalog No.: | CN02034 |
| CAS No.: | 73-03-0 |
| Molecular Formula: | C10H13N5O3 |
| Molecular Weight: | 251.24 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The body of Cordyceps sienesis (Berkeley) Saccardo |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: | OCC1CC(C(O1)n1cnc2c1ncnc2N)O |
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| Description | Cordycepin, which is a nucleoside derivative isolated from Cordyceps, inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner. |
| Target | MMP-1 MMP-3 |
| In Vitro | Cordycepin is a potent inhibitor of IL-1β-induced chemokine production and MMP expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs. The effect of Cordycepin on cellular toxicity of RASFs is assessed using MTT assay. Treatment of RASFs with Cordycepin (50 μM or 100 μM) for 24 h does not cause any significant change in cell viability. However, cell viability is slightly decreased when cells are incubated with 100 μM Cordycepin for 48 h[1]. |
| Cell Assay | RASFs (2×104 cells/well) are treated with various concentrations of Cordycepin (50 μM or 100 μM). After incubation for 1 h, 12 h and 24 h, cells are washed twice with PBS, MTT (0.5 mg/mL PBS) is added to each well and incubated at 37°C for 30 min. Formazan crystals formed are dissolved by adding DMSO (100 μL/well) and the absorbance is read at 570 nm using a microplate reader[1]. |
| Density | 1.9±0.1 g/cm3 |
| Boiling Point | 627.2±65.0 °C at 760 mmHg |
| Flash Point | 333.1±34.3 °C |
| Exact Mass | 251.101837 |
| PSA | 119.31000 |
| LogP | -0.41 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Storage condition | −20°C |