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Linderalactone
| Product Name | Linderalactone |
| Price: | $117 / 20mg |
| Catalog No.: | CN09509 |
| CAS No.: | 728-61-0 |
| Molecular Formula: | C15H16O3 |
| Molecular Weight: | 244.29 g/mol |
| Purity: | >=98% |
| Type of Compound: | Sesquiterpenoids |
| Physical Desc.: | Powder |
| Source: | The roots of Lindera aggregata |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CC1=CCCC2=C[C@H](c3c(C1)occ3C)OC2=O |
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| Description | Linderalactone is an important sesquiterpene lactone isolated from Radix linderae. Linderalactone inhibits cancer growth by modulating the expression of apoptosis-related proteins and inhibition of JAK/STAT signalling pathway. Linderalactone also inhibits the proliferation of the lung cancer A-549 cells with an IC50 of 15 µM[1][2]. |
| In Vitro | Linderalactone (0-100 μM; 24 hours; A549 cells) treatment inhibits the growth of A549 cells concentration-dependently. The IC50 of linderalactone is 15 µM[1]. Linderalactone (7.5-30 μM; A549 cells) treatment induces apoptosis in A549 cells in a dose-dependent manner[1]. Linderalactone (7.5-30 μM; 24 hours; A549 cells) treatment induces G2/M cell cycle arrest of A549 cells dose-dependently[1]. Linderalactone (7.5-30 μM; A549 cells) inhibits the expression of STAT1, JAK1 and JAK2. Linderalactone could also inhibit the phosphorylation of pSTAT1, pSTAT-2, pJAK1 and pJAk2[1]. Cell Viability Assay[1] Cell Line: Lung cancer A549 cells Concentration: 0 μM, 1.6 μM, 3.2 μM, 6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM Incubation Time: 24 hours Result: Inhibited the growth of A549 cells concentration-dependently. Apoptosis Analysis[1] Cell Line: Lung cancer A549 cells Concentration: 7.5 μM, 15 μM, 30 μM Incubation Time: Result: Induced apoptosis in A549 cells in a dose-dependent manner. Cell Cycle Analysis[1] Cell Line: Lung cancer A549 cells Concentration: 7.5 μM, 15 μM, 30 μM Incubation Time: 24 hours Result: Induced G2/M cell cycle arrest. Western Blot Analysis[1] Cell Line: Lung cancer A549 cells Concentration: 7.5 μM, 15 μM, 30 μM Incubation Time: Result: Inhibited the JAK/STAT pathway in A549 cells. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 437.9±45.0 °C at 760 mmHg |
| Flash Point | 218.6±28.7 °C |
| Exact Mass | 244.109940 |
| PSA | 39.44000 |
| LogP | 3.27 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Storage condition | 2-8C |