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5'-Methoxynobiletin
| Product Name | 5'-Methoxynobiletin |
| Price: | Inquiry |
| Catalog No.: | CN04594 |
| CAS No.: | 6965-36-2 |
| Molecular Formula: | C22H24O9 |
| Molecular Weight: | 432.42 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Powder |
| Source: | The herbs of Eupatorium coelestinum |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
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| Description | 5'-Methoxynobiletin is a potent and orally active antinociceptive and anti-inflammatory agent. 5'-Methoxynobiletin is a polymethoxyflavone, that can be isolated from A. conyzoides[1][2]. |
| In Vivo | 5'-Methoxynobiletin (5mg /kg, 腹腔注射) 可显著降低白细胞计数、中性粒细胞流入和渗出液中的蛋白质浓度，并降低几种促炎介质的水平[2]。< br/>5'-Methoxynobiletin (100 mg/kg，口服，一次) 显示出抗伤害和抗炎活性[2]。 5'-Methoxynobiletin (10 mg/kg，静脉注射；50 mg/kg，口服；一次) 在大鼠体内的口服生物利用度较低，约为 8-11%[2]。 Animal Model: Swiss mice (female)[2] Dosage: 100 mg/kg Administration: Orally Result: Significantly reduced both phases of formalin-induced nocifensive behavior after 15, 30 and 60 min of oral administration, when compared to control groups. In the neurogenic phase, inhibitions of 43±3%, 68±6% and 53±5% of the nociceptive response were observed, while for the infammatory phase inhibitions were 70±8%, 91±3% and 85±3% after 15, 30 and 60 min of the oral administration of 5'-Methoxynobiletin, respectively. Animal Model: Wistar rats (male)[2] Dosage: 10 mg/kg (IV), 50 mg/kg (oral) Administration: IV, oral, once (Pharmacokinetic Analysis) Result: Pharmacokinetic Parameters of 5'-Methoxynobiletin in male Wistar rats[1]. IV (10 mg/kg) IG (50 mg/kg) λ (h-1) 0.55±0.03 0.29±0.2 Tmax (h) 2.71±0.49 Cmax (mg/L) 0.62±0.21 AUC0-∞ (mg·h/L) 8.19±4.1 3.65±0.8 t1/2 elimination (h) 1.26±0.1 2.31±0.9 CL (L/h.kg) 1.22±0.26 13.68±0.29 Vd, ss (L/kg) 2.24±0.32 47.46±10.10 F (%) 8.67 |
| Density | 1.245g/cm3 |
| Boiling Point | 611.7ºC at 760 mmHg |
| Flash Point | 265ºC |
| Exact Mass | 432.14200 |
| PSA | 94.82000 |
| LogP | 3.52020 |