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Pendulone
| Product Name | Pendulone |
| Price: | $570 / 5mg |
| Catalog No.: | CN04542 |
| CAS No.: | 69359-09-7 |
| Molecular Formula: | C17H16O6 |
| Molecular Weight: | 316.31 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Powder |
| Source: | The herbs of Millettia dielsiana |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Pendulone is a isoflavanquinone with good antiplasmodial activity with an IC50 of 7.0 µM. Pendulone also has antileishmanial, antibacterial and anticancer activity[1][2]. |
| In Vitro | Pendulone displays moderate antiproliferative activity against the A2780 human ovarian cancer cell line, with an IC50 value 19.6 µM[1]. Pendulone displays an IC50 value of 0.43 µg/mL, against L. donovani promastigotes. Pendulone also displays antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus (each IC50 of 1.44 µg/mL)[2]. Pendulone exhibits moderate anticancer activity against human cancer cell lines (SK-MEL, KB, BT-549 and SK-OV-3) with IC50 values of 5.5 and 10.5 μg/mL. Pendulone also shows moderate cytotoxicities against monkey kidney fibroblasts (VERO) and pig kidney epithelial cells (LLC-PK11)[2]. Pendulone shows strong inhibition on the effect of the cell cycle induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in Raji cells[3]. |
| In Vivo | Pendulone shows potent anti-tumor-promoting activity for an in vivo two-stage carcinogenesis test of mouse skin using 7,12-dimethylbenz[a]-anthracene and TPA[3]. |
| Boiling Point | 546.8±50.0 °C(Predicted) |