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Moracin C
| Product Name | Moracin C |
| Price: | Inquiry |
| Catalog No.: | CN03981 |
| CAS No.: | 69120-06-5 |
| Molecular Formula: | C19H18O4 |
| Molecular Weight: | 310.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Phenols |
| Physical Desc.: | Powder |
| Source: | The root barks of Morus alba L. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CC(=CCc1c(O)cc(cc1O)c1cc2c(o1)cc(cc2)O)C |
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| Description | Moracin C, a natural product, is an anti-inflammatory agent. Moracin C inhibits LPS-activated reactive oxygen species (ROS) and nitric oxide (NO) release from cells[1]. |
| Target | COX-2 |
| In Vitro | Moracin C (1-50 μM，24 小时) 抑制 RAW264.7 细胞释放 LPS 激活的活性氧 (ROS) 和一氧化氮 (NO)[1]。 Moracin C (1-50 μM, 2 h) 抑制 RAW264.7 细胞中 iNOS 和 COX-2 的 mRNA 和蛋白表达[1]。 Moracin C (1-50 μM，2 小时) 抑制 LPS 激活的 RAW 264.7 细胞中促炎细胞因子 (IL-1β、IL-6 和 TNF-α) 的产生[1]。 Moracin C (1-50 μM，2 小时) 抑制 LPS 激活的 RAW 264.7 细胞中 p38、ERK 和 JNK 的磷酸化[1]。 RT-PCR[1] Cell Line: RAW 264.7 macrophages Concentration: 1, 10, 25, 50 μM Incubation Time: 2 h Result: Inhibited LPS-induced mRNA expression of iNOS and COX-2. Western Blot Analysis[1] Cell Line: RAW 264.7 macrophages Concentration: 1, 10, 25, 50 μM Incubation Time: 2 h Result: Inhibited LPS-induced TLR4 expression and NF-κB activation. Reduced phosphorylated p38, ERK and JNK levels. |
| In Vivo | Moracin C (100 mg/kg，灌胃，小鼠) 在肠道内吸收迅速、吸收良好，在胃肠道、肝脏、肾脏和肺部分布较广[2]。 Animal Model: Mice (PK Assay)[2] Dosage: 100 mg/kg Administration: Oral gavage Result: Pharmacokinetic profile of Moracin C. Parameters Terminal half-life (min) Cmax (μg/mL) Tmax (min) CLR (mL/min/kg) 100 mg/kg 256 1.79 15 0.032 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 439.4±35.0 °C at 760 mmHg |
| Flash Point | 219.6±25.9 °C |
| Exact Mass | 310.120514 |
| PSA | 73.83000 |
| LogP | 4.46 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |