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Kahweol
| Product Name | Kahweol |
| Price: | $217 / 20mg |
| Catalog No.: | CN08250 |
| CAS No.: | 6894-43-5 |
| Molecular Formula: | C20H26O3 |
| Molecular Weight: | 314.42 g/mol |
| Purity: | >=98% |
| Type of Compound: | Diterpenoids |
| Physical Desc.: | Powder |
| Source: | From Coffee Cherry |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | OCC1(O)CC23CC1CCC3C1(C(CC2)c2ccoc2C=C1)C |
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| Description | Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis. |
| Target | AMPK; adipogenesis; apoptosis[1] |
| In Vitro | Kahweol (20-40 μM; 24 hours) decreases TGF-β-induced CTGF protein expression in AML12 and LX2 cells[1]. Kahweol (20-40 μM; 1 hour) decreases TGF-β-induced phospho-Smad2/3 expression in AML12 cells, but does not affect expression in LX2 cells[1]. Kahweol (20-40 μM) significantly decreased TGF-β-stimulated phospho-ERK and JNK expression in primary hepatocytes only[1]. kahweol (0-25 μg/ml; 6-24 hours) increased the phosphorylation of AMPK and its downstream target Acetyl-CoA carboxylase (ACC) in a time-dependent manner in 3T3-L1 cells[2]. kahweol (0-25 μg/ml) significantly affects protein expression of PPARγ, C/EBPα, FABP4, and FASN, that regulate adipocyte differentiation and lipid metabolism[2]. Western Blot Analysis[2] Cell Line: 3T3-L1 cells Concentration: 0, 5, 10, 25 μg/ml Incubation Time: Result: Reduced PPARγ, C/EBPα, FABP4, and FASN expression in a dose-dependent manner. |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 476.6±45.0 °C at 760 mmHg |
| Flash Point | 242.0±28.7 °C |
| Exact Mass | 314.188202 |
| PSA | 53.60000 |
| LogP | 3.38 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |