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D-Glutamic acid
| Product Name | D-Glutamic acid |
| Price: | Inquiry |
| Catalog No.: | CN00660 |
| CAS No.: | 6893-26-1 |
| Molecular Formula: | C5H9NO4 |
| Molecular Weight: | 147.1 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The seedlings of Pea |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | OC(=O)CC[C@H](C(=O)O)N |
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| Description | D-glutamic acid, an enantiomer of L- glutamic acid, is widely used in pharmaceuticals and foods. |
| In Vitro | Various d-amino acids, such as D-serine, D-aspartic acid (D-Asp), and D-glutamic acid (D-Glu) are widely found in mammals including human beings and they are now thought to be the candidates of novel physiologically active substances and/or biomarkers[1]. D-[Asp/Glu] (4 mg/mL) inhibits IgE binding (75%) to peanuts while D-Glu, D-Asp has no inhibitory effect. IgE is specific for D-[Asp/Glu] and may have the potential for removing IgE or reducing IgE binding to peanut allergens[2]. |
| In Vivo | D-glutamic acid is currently paid attention as a modulator of neuronal transmission and hormonal secretion. It is metabolized only by D-aspartate oxidase in mammals[1]. After intraperitoneal injection, L-glutamate is catabolized via a-ketoglutarate, whereas D-glutamate is converted to n-pyrrolidone carboxylic acid. Carbon 2 of both D- and L-glutamate is converted in the cecum to the methyl carbon of acetate. Both rat liver and kidney catalyze the conversion of D-glutamic acid to n-pyrrolidone carboxylic acid[3]. |
| Animal Admin | Rats: Male albino rats are given injections of L- or D-glutamic acid-2-C14, DL-glutamic acid-5-C14, or D-glutamic acid-5-C14. Injections by stomach tube or into the cecum are performed while the animals are under ether anesthesia. After the rats are killed, the “carcass” and liver glutamic acids are isolated, degraded, and assayed for radioactivity. “Carcass” refers to the entire animal, except liver, including the ished gastrointestinal tract[3]. |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 333.8±32.0 °C at 760 mmHg |
| Flash Point | 155.7±25.1 °C |
| Exact Mass | 147.053162 |
| PSA | 100.62000 |
| LogP | -1.43 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |