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Corynoxine
| Product Name | Corynoxine |
| Price: | $141 / 20mg |
| Catalog No.: | CN01397 |
| CAS No.: | 6877-32-3 |
| Molecular Formula: | C22H28N2O4 |
| Molecular Weight: | 384.47 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The vines of Uncaria rhynchopylla. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CO/C=C([C@H]1C[C@@H]2N(C[C@H]1CC)CC[C@]12C(=O)Nc2c1cccc2)/C(=O)OC |
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| Description | Corynoxine is an enantiomer of Corynoxine B; induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.IC50 value:Tareget: Autophagy inducerIn vivo, Cory promotes the formation of autophagosomes in the fat bodies of Drosophila. By inducing autophagy, Cory promotes the clearance of wild-type and A53T α-syn in inducible PC12 cells. Interestingly, different from its enantiomer Cory B, Cory induces autophagy through the Akt/mTOR pathway as evidenced by the reduction in the levels of phospho-Akt, phospho-mTOR and phospho-p70 S6 Kinase [1]. Corynoxine significantly decreased locomotor activity after oral administration to mice [2]. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 560.8±50.0 °C at 760 mmHg |
| Flash Point | 293.0±30.1 °C |
| Exact Mass | 384.204895 |
| PSA | 67.87000 |
| LogP | 3.31 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Storage condition | -20°C |