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Helenalin
| Product Name | Helenalin |
| Price: | Inquiry |
| Catalog No.: | CN09055 |
| CAS No.: | 6754-13-8 |
| Molecular Formula: | C15H18O4 |
| Molecular Weight: | 262.30 g/mol |
| Purity: | >=98% |
| Type of Compound: | Sesquiterpenoids |
| Physical Desc.: | Powder |
| Source: | The herbs of Helenium microce-phalum |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
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| Description | Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding[1][2]. |
| In Vitro | Helenalin (10 μM; 20-120 minutes) causes complete inhibition of NF-κB DNA binding after 80 minutes[1]. The anti-inflammatory, anti-carcinogenic phytochemical, Helenalin is a potent inhibitor of periodic Skp2 accumulation, an F-box protein mediating SCF E3 ligase ubiquitylation and degradation of both CKIs during S phase progression[3]. Western Blot Analysis[1] Cell Line: Jurkat T cells Concentration: 10 μM Incubation Time: 20-120 minutes Result: Caused complete inhibition of NF-κB DNA binding after 80 minutes. |
| In Vivo | Helenalin (25 mg/kg; i.p.; 6 to 12 hours) administers to immature male ICR mice caused a rapid decrease in hepatic glutathione levels[2]. Animal Model: Immature male ICR mice[2] Dosage: 25 mg/kg Administration: i.p.; 6 to 12 hours Result: Caused a rapid decrease in hepatic glutathione levels. |
| Density | 1.25g/cm3 |
| Boiling Point | 473ºC at 760 mmHg |
| Flash Point | 179.9ºC |
| Exact Mass | 262.12100 |
| PSA | 63.60000 |
| LogP | 1.24630 |