Home
Products
6,8-Diprenylorobol
| Product Name | 6,8-Diprenylorobol |
| Price: | Inquiry |
| Catalog No.: | CN05195 |
| CAS No.: | 66777-70-6 |
| Molecular Formula: | C25H26O6 |
| Molecular Weight: | 422.48 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Yellow powder |
| Source: | The roots of Glycyrrhiza uralensis Fisch |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
| Contact us | |
|---|---|
| First Name: | |
| Last Name: | |
| E-mail: | |
| Question: | |
| Description | 6,8-Diprenylorobol, a prenylated isoflavone, is a nature product that could be isolated from the leaves of Cudrania tricuspidata. 6,8-Diprenylorobol antiproliferative effect and induces apoptosis through activation of p53 and generation of ROS[1][2]. |
| In Vitro | 6,8-Diprenylorobol (20-60 μM; 24-72 h) 抑制 LoVo 和 HCT15 细胞增殖[1]。 6,8-Diprenylorobol (20-60 μM;24 h) 诱导 LoVo 和 HCT15 细胞凋亡，激活 p53 并调控 MAPKs[1]。 6,8-Diprenylorobol (20-60 μM; 1 h) 增加 LoVo 和 HCT15 细胞的 ROS 水平[1]。 Cell Viability Assay[1] Cell Line: LoVo and HCT15 cells Concentration: 20, 40, and 60 μM Incubation Time: 24, 48, and 72 hours Result: Inhibited the growth of LoVo and HCT15 cells in a dose- and dose-dependent manner. Apoptosis Analysis[1] Cell Line: LoVo and HCT15 cells Concentration: 20, 40, and 60 μM Incubation Time: 24 hours Result: Induced apoptosis of LoVo and HCT15 cells in a dose- and time-dependent manner. Western Blot Analysis[1] Cell Line: LoVo and HCT15 cells Concentration: 20, 40, and 60 μM Incubation Time: 24, 48, and 72 hours Result: Decreased the expression of PARP and increased the expression of cleaved PARP. Up-regulated Bax and Bim expressions and downregulated Bcl-2 expression. Up-regulated cleaved caspase-3, -7, -8, and -9 expressions, and down-regulated procaspase-3, -7, -8, and -9 expressions. Decreased the expression of phosphorylated Akt, ERK, JNK, and p38 and increased the expression of FOXO3, p53, p27, and p21. |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 667.1±55.0 °C at 760 mmHg |
| Flash Point | 228.6±25.0 °C |
| Exact Mass | 422.172943 |
| PSA | 111.13000 |
| LogP | 6.94 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |