Home
Products
Chloranthalactone B
| Product Name | Chloranthalactone B |
| Price: | Inquiry |
| Catalog No.: | CN09065 |
| CAS No.: | 66395-03-7 |
| Molecular Formula: | C15H16O3 |
| Molecular Weight: | 244.29 g/mol |
| Purity: | >=98% |
| Type of Compound: | Sesquiterpenoids |
| Physical Desc.: | Powder |
| Source: | The roots of Chloranthus serratus |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
| Contact us | |
|---|---|
| First Name: | |
| Last Name: | |
| E-mail: | |
| Question: | |
| Description | Chloranthalactone B, a lindenane-type sesquiterpenoid, is a nature product that could be isolated from Chinese medicinal herb Sarcandra glabra. Chloranthalactone B inhibits the production of inflammatory mediators by inhibiting the AP-1 and p38 MAPK pathways[1]. |
| In Vitro | Chloranthalactone B (6.25-50 µM; 30 min) 在 LPS 刺激的 RAW264.7 细胞中具有抗炎作用并抑制 NO 产生[1]。 Chloranthalactone B (25 and 50 µM; 30 min) 抑制 LPS 处理的 RAW264.7 细胞中诱导型一氧化氮合酶 (iNOS)、环氧合酶-2 (COX-2)、肿瘤坏死因子 α (TNF-α) 和白介素-1β (IL-1β) 在细胞中的表达[1]。 Chloranthalactone B (25 and 50 µM; RAW264.7 细胞) 以浓度依赖性方式抑制 LPS 诱导的 AP-1 激活[1]。 Chloranthalactone B (25 and 50 µM; RAW264.7 细胞) 抑制 RAW264.7 细胞中 ERK、JNK 和 p38 的磷酸化[1]。 Western Blot Analysis[1] Cell Line: RAW264.7 cells Concentration: 25 and 50 µM Incubation Time: 30 min Result: Inhibited the expression of iNOS, TNF-α, COX-2, and IL-1β in a dose-dependent manner. Inhibited the phosphorylation of ERK, JNK, and p38 in RAW264.7 cells. |
| Exact Mass | 244.11000 |
| PSA | 38.83000 |
| LogP | 2.18690 |