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AG-1024
| Product Name | AG-1024 |
| Price: | Inquiry |
| Catalog No.: | CN00202 |
| CAS No.: | 65678-07-1 |
| Molecular Formula: | C14H13BrN2O |
| Molecular Weight: | 305.17 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | N#CC(=Cc1cc(Br)c(c(c1)C(C)(C)C)O)C#N |
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| Description | AG-1024 (Tyrphostin) inhibits IGF-1R autophosphorylation with IC50 of 7 μM, less potent to IR with IC50 of 57 μM.IC50 value: 7 uM (IGF-1R autophosphorylation); 57 uM (IR) [1]Target: IGF-1R; IRin vitro: AG-1024 blocks the IGF-1 receptor and IR autophosphorylation with IC50 of 7 μM and 57 μM, respectively. AG-1024 also inhibits the receptor tyrosine kinase activity towards exogenous substrates (TKA) with IC50 values of 18 μM and 80 μM, respectively [1]. Human breast cancer cell line MCF-7 exposure to Tyrphostin AG 1024 inhibited proliferation and induced apoptosis in a time-dependent manner, and the degree of growth inhibition for IC20 plus irradiation (4 Gy) was up to 50% compared to the control. Examination of Tyrphostin AG 1024 effects on radiation response demonstrated a marked enhancement in radiosensitivity and amplification of radiation-induced apoptosis [2]. AG-1024 significantly inhibits melanoma cell proliferation with an IC50 of <50 nM in the absence of serum, by blocking MAPK/ERK2 signaling, subsequently rapidly inducing pRb dephosphorylation and activation, and eventually the formation of growth suppressive pRb-E2F complexes [3].in vivo: Administration of AG-1024 at a dose of 30 μg for 10 days significantly inhibits the tumor growth of Ba/F3-p210 xenograft in mice [4]. |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 379.8±42.0 °C at 760 mmHg |
| Flash Point | 183.5±27.9 °C |
| Exact Mass | 304.021118 |
| PSA | 67.81000 |
| LogP | 4.18 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Storage condition | −20°C |