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Catechin 7-O-beta-D-glucopyranoside
| Product Name | Catechin 7-O-beta-D-glucopyranoside |
| Price: | $176 / 10mg |
| Catalog No.: | CN04200 |
| CAS No.: | 65597-47-9 |
| Molecular Formula: | C21H24O11 |
| Molecular Weight: | 452.4 g/mol |
| Purity: | >95% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Powder |
| Source: | The herbs of Spiraea hypericifolia L. |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: |
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| Description | Catechin 7-O-beta-D-glucopyranoside is an orally active natural product found in Ulmus davidiana and Paeonia obovata. Catechin 7-O-β-D-glucopyranoside shows antioxidant and anti-inflammatory activities, and attenuates mitochondrial dysfunction. Catechin 7-O-beta-D-glucopyranoside can be used in intestinal inflammatory disease research[1][2][3]. |
| In Vitro | Catechin 7-O-β-D-glucopyranoside (10 μg/mL; 24 h) shows protective effect against Streptozotocin-induced cell damage by its antioxidant effects and the attenuation of mitochondrial dysfunction[3]. Western Blot Analysis[3] Cell Line: RINm5F rat pancreatic β-cells Concentration: 10 μg/mL Incubation Time: 24 hours Result: Increased the MnSOD level attenuated by Streptozotocin treatment. Restored the Streptozotocin-induced reduction in mitochondrial CAT level. |
| In Vivo | Catechin 7-O-β-D-glucopyranoside (intraperitoneal injection; 10 mg/kg; once) treatment shows mild protective effect against lethality induced by LPS/D-GalN[1]. Catechin 7-O-β-D-glucopyranoside (oral administration; 10 mg/kg; once daily; 7 d) treatment prevents intestinal inflammatory damages in TNBS model of rat colitis[2]. Animal Model: Mice injected with LPS/D-GalN[1] Dosage: 10 mg/kg Administration: Intraperitoneal injection; 10 mg/kg; once Result: Showed 80% LPS/DGalN-induced lethality in mice. Animal Model: Rat model of trinitrobenzenesulfonic acid (TNBS)-induced colitis [2] Dosage: 10 mg/kg Administration: Oral administration; 10 mg/kg; once daily; 7 days Result: Suppressed body weight loss and intestinal inflammatory damages in TNBS-induced colitic rats. Reduced myeloperoxidase activity and malondialdehyde level, but increased glutathione level in the TNBS colitic rats. |
| Exact Mass | 203.06900 |
| PSA | 75.76000 |
| LogP | 0.46550 |