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Scoulerine
| Product Name | Scoulerine |
| Price: | $453 / 10mg |
| Catalog No.: | CN00982 |
| CAS No.: | 6451-73-6 |
| Molecular Formula: | C19H21NO4 |
| Molecular Weight: | 327.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The herbs of Corydalis dubia. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(O)c(cc1)OC |
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| Description | Scoulerine ((-)-Scoulerine), an isoquinoline alkaloid, is a potent antimitotic compound. Scoulerine is also an inhibitor of BACE1 (ß-site amyloid precursor protein cleaving enzyme 1). Scoulerine inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells[1]. |
| In Vitro | Scoulerine ((-)-Scoulerine) inhibits mini-panel of human leukemic cells, MOLT-4 (WT), Jurkat (TP53 mutated), Raji (TP53 mutated), HL-60 (TP53 null), U-937 (TP53 mutated), and HEL 92.1.7 (wild-type), with IC50s ranging from 2.7 µM to 6.5 µM[1]. Scoulerine (2.5-20 µM; 24 hours) decreases proliferation of Jurkat and MOLT-4 cells[1]. Scoulerine (2.5-20 µM; 24 hours) induces MOLT-4 and Jurkat cells apoptosis[1]. Scoulerine induces G2 or M cell cycle arrest[1]. Scoulerine (2.5-5 µM; 24 hours) shows an upregulation of p53 protein in p53 wild-type MOLT-4 cells[1]. Scoulerine (2.5-5 µM; 24-48 hours) activates caspase-3/7, -8 and -9 in a dose-dependent manner[1]. Scoulerine (5-10 µM; 24 hours) disrupts microtubule structure of A549 lung carcinoma cells[1] Cell Proliferation Assay[1] Cell Line: Jurkat and MOLT-4 cells Concentration: 2.5, 5, 10, 15 and 20 µM Incubation Time: 24 hours Result: Significantly reduced the viability and proliferation of Jurkat and MOLT-4 cells in a dose dependent manner. Apoptosis Analysis[1] Cell Line: MOLT-4 and Jurkat cells Concentration: 2.5, 5, 10, 15 and 20 µM Incubation Time: 24 hours Result: Induced MOLT-4 and Jurkat cells apoptosis. Cell Cycle Analysis[1] Cell Line: Jurkat and MOLT-4 leukemic cells Concentration: 2.5-20 µM Incubation Time: 16 hours Result: Induced cell cycle arrest at the G2/M transition. Western Blot Analysis[1] Cell Line: MOLT-4 cells Concentration: 2.5, 5 µM Incubation Time: 24 hours Result: Showed an upregulation of p53 protein in p53 wild-type MOLT-4 cells. |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 503.3±50.0 °C at 760 mmHg |
| Flash Point | 258.2±30.1 °C |
| Exact Mass | 327.147064 |
| PSA | 62.16000 |
| LogP | 2.16 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |