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Alstonine
| Product Name | Alstonine |
| Price: | Inquiry |
| Catalog No.: | CN01376 |
| CAS No.: | 642-18-2 |
| Molecular Formula: | C21H21N2O3 |
| Molecular Weight: | 349.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Yellow powder |
| Source: | The herbs of Catharanthus roseus |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Alstonine is a major indole alkaloid compound of a plant-based remedy. Alstonine has antipsychotic, anxiolytic, anticancer and antimalarial properties[1]. |
| In Vitro | Alstonine has the capacity to distinguish cancer DNA from healthy tissue DNA; it inhibits DNA in vitro synthesis when DNA from different cancerous tissues or cells is used as template. Practically without effects on DNA from healthy tissues[1]. |
| In Vivo | In mice models Alstonine shows a clear, dose-dependent, potent antipsychotic profile. Alstonine (i.p.) prevents amphetamine-induced lethality, with active doses within the range of 0.5-2.0 mg/kg[1]. Alstonine (0.1, 0.5 and 1.0 mg/kg) prevents MK-801 induced hyperlocomotion. Because Alstonine partially reverses MK-801-induced increase in locomotion both at the hole-board and locomotor activity cages[1]. Alstonine successfully treats a relatively important proportion of BALB/C mice inoculated with transplantable YC8 lymphoma ascites cells as well as Swiss mice bearing Ehrlich ascites carcinoma cells[1]. |
| Density | 0.9±0.1 g/cm3 |
| Boiling Point | 189.9±0.0 °C at 760 mmHg |
| Flash Point | 65.0±8.0 °C |
| LogP | 3.20 |
| Vapour Pressure | 0.8±0.3 mmHg at 25°C |