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1,4-Anthraquinone
| Product Name | 1,4-Anthraquinone |
| Price: | Inquiry |
| Catalog No.: | CN05858 |
| CAS No.: | 635-12-1 |
| Molecular Formula: | C14H8O2 |
| Molecular Weight: | 208.2 g/mol |
| Purity: | >=98% |
| Type of Compound: | Quinones |
| Physical Desc.: | Powder |
| Source: | |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | O=C1C=CC(=O)c2c1cc1ccccc1c2 |
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| Description | 1,4-Anthraquinone is a potent anticancer agent. 1,4-Anthraquinone blocks nucleoside transport, inhibits macromolecule synthesis, induces DNA fragmentation, and decreases the growth and viability of cancer cells. 1,4-Anthraquinone can be used to research anti-leukemia[1]. |
| Target | DNA/RNA synthesis[1] |
| In Vitro | 1,4-Anthraquinone (2.62 nM-1.6 μM; 4 days) induces significant antiproliferative and cytotoxic effects in L1210 cells after 4 days at 6.55 nM; inhibits cell viability with IC50s of 100 nM at day 2 and 25 nM at day 4[1]. 1,4-Anthraquinone (40.96 nM-25 μM; 30 min; L1210 cells) inhibits nucleoside transport by 71 and 92% and DNA synthesis by 84 and 96% at 4 and 10 μM, respectively, and are both irreversible upon drug removal[1]. 1,4-Anthraquinone (0.1024-25 μM; 3 h) inhibits the rates of RNA and protein syntheses (IC50 = 2 μM) in a dose-dependent manner[1]. Cell Proliferation Assay[1] Cell Line: L1210 cells Concentration: 2.62 nM-1.6 μM Incubation Time: 4 days Result: Induced significant antiproliferative and cytotoxic effects after 4 days at 6.55 nM. Cell Viability Assay[1] Cell Line: L1210 cells Concentration: 2.62 nM-1.6 μM Incubation Time: 4 days Result: Inhibited cell viability with IC50s of 100 nM at day 2 and 25 nM at day 4. |
| Density | 1.328 g/cm3 |
| Boiling Point | 406ºC at 760 mmHg |
| Flash Point | 152ºC |
| Exact Mass | 208.05200 |
| PSA | 34.14000 |
| LogP | 2.77500 |