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L-Phenylalanine
| Product Name | L-Phenylalanine |
| Price: | $12 / 20mg |
| Catalog No.: | CN01052 |
| CAS No.: | 63-91-2 |
| Molecular Formula: | C9H11NO2 |
| Molecular Weight: | 165.19 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The seeds of Glycine max (L.) Merr |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | NC(C(=O)O)Cc1ccccc1 |
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| Description | L-Phenylalanine is an antagonist at α2δ calcium channels with a Ki of 980 nM. IC50 Value: 980 nM [1]Target: Calcium ChannelL-Phenylalanine (LPA) is an electrically neutral amino acid, one of the twenty common amino acids used to biochemically form proteins. In the brain, L-phenylalanine is a competitive antagonist at the glycine binding site of NMDA receptor and at the glutamate binding site of AMPA receptor [2, 3]. At the glycine binding site of NMDA receptor L-phenylalanine has an apparent equilibrium dissociation constant (KB) of 573 ?M estimated by Schild regression [4] which is considerably lower than brain L-phenylalanine concentration observed in untreated human phenylketonuria [5]. L-Phenylalanine also inhibits neurotransmitter release at glutamatergic synapses in hippocampus and cortex with IC50 of 980 nM, a brain concentration seen in classical phenylketonuria, whereas D-phenylalanine has a significantly smaller effect [3]. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 307.5±30.0 °C at 760 mmHg |
| Flash Point | 139.8±24.6 °C |
| Exact Mass | 165.078979 |
| PSA | 63.32000 |
| LogP | 1.11 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |