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Rauwolscine hydrochloride
| Product Name | Rauwolscine hydrochloride |
| Price: | Inquiry |
| Catalog No.: | CN00568 |
| CAS No.: | 6211-32-1 |
| Molecular Formula: | C21H27ClN2O3 |
| Molecular Weight: | 390.9 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1.Cl |
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| Description | Rauwolscine hydrochloride is a potent and specific α2 adrenergic receptor antagonist with a Ki of 12 nM. |
| Target | Ki: 12 nM (α2 adrenergic receptor)[1] |
| In Vitro | [3H]Rauwolscine binding to α2 adrenergic receptor is reversible, stcreospccific, and saturable. [3H]Rauwolscine specifically labels both the high and low affinity states of the α2 adrenergic receptor in brain membranes[1]. [3H]Rauwolscine also behaves as a 5-HT1A receptor agonist and this conclusion is compatible with earlier functional studies, indicating that rauwolscine (as well as yohimbine) has agonistic properties at the level of 5-HT autoreceptors[2]. When using [3H]5-HT as a radioligand, rauwolscine is determined to have relatively high affinity for the human receptor (Ki human=14.3 nM, Ki rat=35.8 nM)[3]. Saturation studies shows that the affinity of [3H]Rauwolscine is similar in mouse, rat, rabbit, dog (2.33-3.03 nM) except man where it is significantly higher (0.98 nM) [4]. |
| Density | 1.31 g/cm3 |
| Boiling Point | 543ºC at 760 mmHg |
| Flash Point | 282.2ºC |
| Exact Mass | 390.171021 |
| PSA | 65.56000 |
| LogP | 3.38700 |
| Storage condition | Store at RT |